Time-Dependent Toxicities of Quorum Sensing Inhibitors toAliivibrio fischeriandBacillus subtilis
نویسندگان
چکیده
منابع مشابه
Interactions among Quorum Sensing Inhibitors
Many pathogenic bacteria use quorum sensing (QS) systems to regulate the expression of virulence genes in a density-dependent manner. In one widespread QS paradigm the enzyme LuxI generates a small diffusible molecule of the acyl-homoserine lactone (AHL) family; high cell densities lead to high AHL levels; AHL binds the transcription factor LuxR, triggering it to activate gene expression at a v...
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Many opportunistic pathogenic bacteria rely on quorum sensing (QS) circuits as central regulators of virulence expression. In Pseudomonas aeruginosa, QS-regulated gene expression contributes to the formation and maintenance of biofilms and their tolerance to conventional antimicrobials and the host innate immune system. Therefore, QS is an obvious target for a novel class of antimicrobial drugs...
متن کاملStructure of the Bacillus subtilis quorum-sensing peptide pheromone ComX.
The ComX pheromone is an extracellular signaling molecule that stimulates natural competence in response to crowding in the gram-positive bacterium Bacillus subtilis. The pheromone is formed by isoprenylation of an inactive precursor peptide, but its precise structure is not known. Here we report the structure of the ComX pheromone, showing that addition of a geranyl group to a tryptophan resid...
متن کاملQuorum Sensing: It’s About Time
Quorum sensing is a form of cell-to-cell communication by which bacteria communicate by secreting signaling molecules called autoinducers that help regulate gene expression. Quorum sensing was first detected in Photobacterium fischeri [1]. A specific acylated homoserine lactone was found to regulate transcription of the luciferase operon resulting in light emission [2]. A related organism, Vibr...
متن کاملQuorum Sensing in Microbial Virulence
Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by microorganisms to elicit expression of target genes in response to environmental stimuli or need of microbial communities. Type I system acts by using acyl homoserine lactones as signals to trigger the ex...
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ژورنال
عنوان ژورنال: Dose-Response
سال: 2019
ISSN: 1559-3258,1559-3258
DOI: 10.1177/1559325818822938